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LARGE SCALE MANUFACTURING PROCESS

LARGE SCALE MANUFACTURING PROCESS


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1 Introduction to Concept of Bioprocess Engineering
1.1 Introduction
1.2 Definition of Bioprocess Engineering
1.3 Overview of Bioprocess and Scale of Operation
1.3.1 Stages in SCALE Up Process
1.3.2 Scale Up Studies
1.3.3 Scale Down Studies
1.4 Global Trend of Biotechnology
2 Introduction to Simple Engineering, Calculations, Mass and Energy Balances
2.1 Introduction
2.2 Physical Variables, Dimensions and Units
2.2.1 Physical Variables
2.2.2 Dimensions
2.2.3 Units
2.3 Force and Weight
2.4 Measurement Conventions
2.5 Mass Balance
2.6 Law of Mass Conservation
2.7 Growth Stoichiometry and Elemental Balances
2.8 Energy Balance
2.8.1 Intensive and Extensive Properties
2.8.2 General Energy Balance Equation
3 Bioreactor Design and Construction
3.1 Introduction
3.2 Bioreactor - Construction, Design and Operations
3.3 Design of Stirred Tank Bioreactor
3.4 Materials of Construction
3.4.1 Vessel Materials - Stainless Steel
3.4.2 Welding of Chrome - Nickel Steel
3.4.3 Application in Vessel Construction
3.5 Surface Treatment
3.5.1 Mechanical Surface Treatment
3.5.2 Chemical Surface Treatment
3.5.3 Electrochemical Surface Treatment
3.5.4 Finish
3.6 Design Consideration
3.6.1 Dead Spaces and Cavities
3.6.2 Tightness
3.7 Components of the Biotechnological Vessel
3.7.1 Rotating Seals
3.7.2 Ports
3.7.3 Viewing Glasses
3.7.4 Manways
3.7.5 Baffles
3.7.6 Spargers
3.7.7 Nozzles
3.7.8 Heating Jackets
3.7.9 Coils
3.7.10 Drain Valve
3.7.11 Steam Locks
3.7.12 Safety
4 Air and Media Sterilization
4.1 Introduction
4.2 Mechanisms of Capture of Particle in Air
4.3 Depth and Screen Filters
4.3.1 Depth Filters
4.3.2 Screen Filters
4.3.3 Absolute Filtration
4.3.4 Cartridge Air Filtration
4.3.5 Depth Filtration using Fibrous Materials
4.4 Size, Testing and Validation of Filters for Air Sterilization
4.5 Principles of Media Sterilization
4.5.1 Media Sterilization by Removal
4.5.2 Media Sterilization by Inactivation
4.5.3 Thermal Death Kinetics
4.6 Design of Sterilization Cycle using Kinetics of Thermal Death
4.7 The Dispersion on Model
4.8 Equipment in Sterilization
4.9 Air Shower
5 Media for Large Scale Processes and their Optimization
5.1 Introduction
5.2 Constituents of Media
5.2.1 Carbon Source
5.2.2 Nitrogen Source
5.2.3 Minerals
5.2.4 Oxygen
5.2.5 Specific Nutrients
5.2.6 Inhibitors
5.2.7 Inducers and Elicitors
5.2.8 Precursors
5.2.9 Cell Permeability Modifiers
5.3 Media for Mammalian Cell Culture
5.4 Estimation and Quantification
5.5 Media Formulation
5.5.1 Chemically Defined Media
5.5.2 Complex Media
5.5.3 Media Formulation for Mammalian Cell Cultures
5.6 Medium Optimisation
5.6.1 Plackett - Burman Design
5.6.2 Response Surface Design
5.7 Costing of Media
6 Biotransformation and Microbial Cultures
6.1 Introduction
6.2 Types of Bioprocess
6.3 Production of Biocatalysts
6.4 Oxidative Enzyme - Catalyzed Reactions
6.4.1 Polyphenol Oxidase Biotransformations
6.4.2 Peroxidase - Cataylzed Biotransformations
6.4.3 Laccase Biotransformations
6.5 Bacterial Systems
6.6 Microbial Cultures
6.6.1 Batch Fermentation
6.6.2 Microbial Growth and Specific Growth Rate
6.6.3 Fed - Batch Fermentation
6.6.4 Continuous Fermentation and Kinetics
6.7 Cell Recycle
6.8 The Monod Model
6.9 Effect of Substrate Concentration
6.9.1 Substrate Uptake and Product Formation
6.9.2 Solid - State Fermentation
7 Enzyme and Cell Immobilization
7.1 Introduction
7.2 Enzyme and Cell Immobilization
7.3 Properties of Enzymes to be Immobilized
7.4 Techniques and Supports for Immobilization
7.4.1 Entrapment
7.4.2 Covalent Binding
7.4.3 Adsorption
7.4.4 Encapsulation
7.5 Properties of Immobilized Enzymes (Km Ks Cycle Time Half Life, Inactivation Kinetics)
7.6 Kinetics of Inactivation
8 Measurement and Control of Bioprocess Parameters
8.1 Introduction
8.2 Cell Growth
8.3 pH Measurement
8.4 Temperature
8.5 Substrate Consumption
8.6 Product Formation
8.7 Substrate Uptake and Product Yield
8.8 Measurement of Oxygen / Carbon Dioxide Uptake Evolution
8.8.1 Dissolved Oxygen
8.8.2 Carbon Dioxide
8.9 Specific Rate of Consumption Substrate and Formation of Product
8.10 Strategies of Fermentation Control
8.11 Computer Controlled Fermentation
8.12 Formation of Heat and Cooling Requirement
8.13 Foam and its Control
8.14 Oxygen Uptake
8.15 Viscosity
8.16 Scale Up of Fermentation
9 Quality Control and Assurance
9.1 Introduction
9.2 Quality Control
9.3 Quality Assurance
9.3.1 Quality Assurance; Establishing Confidence in Reported Data
9.3.2 Definition of Good Laboratory Practices
9.4 Good Manufacturing Practices
9.5 Ames Test
10. Product Recovery and Down Stream Processing in Fermentation and Bioprocess Technology
10.1 Introduction
10.2 Solid - Liquid Separation
10.2.1 Flocculation
10.2.2 Filtration
10.2.3 Centrifugation
10.2.4 Cell Disruption
10.2.5 Extraction - Liquid - Liquid
10.2.6 Precipitation
10.2.7 Distillation
10.2.8 Evaporation
10.2.9 Chromatography
10.2.10 Adsorption
10.2.11 Concentration
10.2.12 Lyophilization / Freeze-drying
10.2.13 Spray Drying
11. Industrial Processes and Applications
11.1 Introduction
11.2 Description of Manufacture of Enzymes
11.3 Antibiotics
11.3.1 Cephalosporins
11.3.2 Penicillin
11.4 Amino Acids
11.4.1 L-glutamate
11.4.2 L-phenylalanine
11.4.3 Lysine
11.4.4 Other Amino Acids
11.5 Vitamins
11.5.1 Ascorbic Acid (Vitamin C)
11.5.2 Vitamin B12
11.6 Ethanol
11.7 Vaccines
11.7.1 Foot-and-Mouth Disease
11.7.2 DTP
11.7.3 New Castle Disease
11.8 Single Cell Protein
12. Bioprocess Economics
12.1 Introduction
12.2 Choice of Process
12.3 Process / Cost Analysis
12.3.1 Capital Cost Estimate
12.3.2 Large Scale Equipment and Utilities
12.3.3 Skid - Mounted Equipment
12.4 Manufacturing Cost Estimates, Operating Cost
12.4.1 Raw Materials
12.4.2 Labor
12.4.3 Utilities
12.4.4 Other Cost
12.5 Fixed Cost and Variable Costs
12.6 Depreciation
12.7 Selection of Pricing
12.8 Profitability
12.9 Scales of Operations

Academic Details

  • Phase Graduation

  • Stream Science

  • Branch Biotechnology

  • Standard/Year Thirdyear

  • Semester Iv

  • Medium English

  • Board/University Pune

  • Subject Large Scale Manufacturing Process

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LARGE SCALE MANUFACTURING PROCESS

LARGE SCALE MANUFACTURING PROCESS

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